The Via Francigena del Sud offers diverse weather patterns as it stretches from Rome to Leuca through regions like Lazio, Campania, and Apulia. March, April, and September provide particularly favorable conditions for walking, balancing warmth and sunshine with moderate rainfall. The route allows for an exploration of contrasting climates and landscapes, whether in the vibrancy of spring or the warmth of late summer. Travelers can expect a mixture of temperatures along the journey through these historic Italian regions.